Great question! After much research, Smart-n-Healthy chose this probiotic specifically for our therapeutic sprays because of its safety, benefits and because its endospores (very tough outer shells) can withstand extreme variations in environmental conditions. We haven’t had any issues with the billions of probiotics dying in transit or soon after.

Our probiotic sprays, FemBioticsMenBiotics and BabyBiotics (and Probiotic Pet Solutions) do NOT need to be refrigerated and will continue to thrive. And they would be cold upon application, so we are happy they don’t need to be refrigerated!

The formula is highly concentrated with probiotics. If for any reason the probiotics would die, the formula would have an extremely foul, rotten smell. We know this from our extensive research. No reported cases.